Format
The general format of the preliminary examination will consist of one scholarly written proposal that focuses on a topic approved by the Prelim Committee. This proposal should be in the general format of an NIH grant application. Each proposal will normally be for a research project that can be accomplished by a single investigator, plus a technician and 1-2 students, over a 3-5 year period. The suggested format is specified below. The written proposal will provide the basis for an oral exam, during which the student's knowledge of the subject area and general biological concepts will be explored.
The goals of the prelim process are:
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To formulate relevant, important testable models or hypotheses based on existing data and devise experiments that specifically and directly test these models or hypotheses.
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To achieve a thorough understanding of the key experiments in the field of choice. What is known already? What does the scientific literature suggest we need to know to further our understanding of this area? What are the gaps and inconsistencies in the published data?
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To express a line of experimentation in grant application format.
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To develop critical skills in evaluating the benefits and risks of specific experimental directions.
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To effectively present and defend one’s ideas orally before an examining committee.
The expectation of the committee is that the student will demonstrate mastery of the basic principles and methods of modern biological science, as taught in the first year graduate classes, journal clubs, and laboratory experiences. This demonstration of mastery will be conveyed during both the written and oral parts of the examination. The student should expect to be asked about all fundamental aspects of modern biology, including, but not limited to, a deep understanding of the basic principles of genetics. The candidate must be knowledgeable in all aspects of the first year course material as a prerequisite for satisfactory performance on the preliminary examination.
During the preparation of the written proposal the student is encouraged to contact other scientists to discuss the model to be tested, experimental ideas, technical questions, or questions on grant writing. This includes colleagues, faculty, and scientists off campus (see Helpful Hints below). The student is encouraged to seek input from the Prelim Committee regarding specific aims and the overall logic of the proposal, but not to discuss details that could impact the final exam. The student should not obtain any input from their Ph.D. thesis advisor. Overall, the basic direction and overall logic of the proposal must originate from the student.