John Atkins, Ph.D., D.Sc.

The exceptions to standard decoding provide us with insights that contribute to our understanding of standard decoding but they are also important in their own right. Recoding is widely used by viruses, especially plant viruses, and current work is revealing the critical setting of this phenomenon in retroviruses and identifying new regulatory control points.

E. Gueguen, N.W. Wills, J.F. Atkins and E. Cascales. Transcriptional frameshifting rescues Citrobacter rodentium Type VI secretion by the production     of two length variants from the prematurely interrupted tssM gene. PLOS Genet.  In press.

H.J. Kwun, T. Toptan, S.R. da Silva, J.F. Atkins, P.S. Moore and Y. Chang.     2014. Human DNA Tumor viruses generate alternative reading frame proteins through repeat sequence recoding. Proc. Natl. Acad. Sci. USA 111, E4342-4349.

G. Loughran, M.-Y. Chou, I.P. Ivanov, I. Jungries, M. Kellis, A.M. Kiran, P.V. Baranov and J.F. Atkins. 2014. Evidence of efficient stop codon readthrough in four mammalian genes. Nucl. Acids Res. 42, 8928-8938.

E. Samatova, A.L. Konevega, N.M. Wills, J.F. Atkins and M.V. Rodnina. 2014. High-efficiency translational bypassing of 50 non-coding nucleotides specified by mRNA structure and nascent peptide. Nature Communications 5: 4459.